Even in 2021 security is something for experts with console commands and UIs that look like back in 2010 – security doesn’t need a fancy looking UI. Nevertheless integration could be a bit better be it login in to *nix systems that requires a bit of fiddling depending on init-system and authentication. On Windows a Yubikey logs in without any password if the group policy doesn’t disable this which requires admin powers. And most consumer devices simply start as desktop. Sure you need to first pick your Yubikey with a bit of expertise then set up the slots according to your needs e.g. slot #1 left as Fido/U2F and second as Authenticator/HMAC-secret. Finally recent Yubikeys come with flexible Smartcard key slots, too supporting elliptic curves. I do not log in to my desktop with my Yubikey but use it as Smartcard to encrypt and sign mails – configuration through GPG command line. And it serves as U2F with slot #1 and with its HMAC as 2nd factor for keystores and Authenticator-replacement Yubico Authenticator: https://www.yubico.com/products/services-software/download/yubico-authenticator/. And maybe think about your lost or stolen smartphone giving access to anything through its apps.