Thanks for your excellent review of the Evoluent Vertical Mouse 4. I've just got one for work due to increasing pain in my wrist/hands from RSI. Did you find it took a while for your wrists to stop being painful after you started using the Evoluent VM, or was it quite quick?
I've also just got the Microsoft 4000 (natural ergonic keyboard), which I see you're quite fond of! How have you found it? I'm hoping it will also help reduce the strain to my wrists - it seems quite comfortable, the only thing is it is quite wide so I find I have to reach over more to move the mouse.